Patient-Specific Technology: Where Biomechanics Meets Individual Bone Structure

OptimalPSI develops patient-specific, optimized spinal fusion implants that aim to reduce subsidence risk and improve outcomes.

Explore Our Pre-Clinical Evidence

Off-the-shelf OptimalPSI

89%

Subsidence risk reduction

vs. off-the-shelf implants in pre-clinical computational modeling*,** Pre-clinical result. Not established in clinical use.

~2×

Subsidence resistance improvement

Validated in human cadaveric testing*** Pre-clinical result. Not established in clinical use.

Patent-pending

Technology

Physics-based optimization, automated by AI

AI-enabled

Design process

Automated workflow from CT scan to optimized implant

Patient-Specific Implants Optimized for Load Distribution, Not only Anatomy

The Problem

A substantial number of lumbar spine fusion patients experience subsidence with traditional implants¹, potentially leading to post-operative pain and revision surgery.^2,3

Our Solution

OptimalPSI's optimization algorithm designs each patient-specific implant based on the patient's unique fit and mechanics, aiming to reduce subsidence and enable surgeons to treat patients with confidence.

The Result

Pre-clinical studies show reduced subsidence risk that aim to enable surgeons to confidently treat patients and improve patient outcomes.

Beyond Patient-Specific Anatomy: Patient-Specific Biomechanical Architecture

Not all patient-specific implants are created equal. While others focus on matching anatomy, OptimalPSI goes further. Using optimization to account for the patient's bone structure and load distribution, our technology creates a customized TLIF implant with variable stiffness and porosity that distributes load precisely where the bone can handle it, aiming to reduce subsidence risk by 75% compared to anatomy-only patient-specific solutions*.

Level 1

Standard off-the-shelf

Technology: One-geometry-fits-all design

Clinical challenge: High subsidence rates reported for TLIF procedure¹

Level 2

Patient-specific shape

Technology: Custom anatomy matching

Design focus: Anatomical conformity, to treat deformities

Level 3 Patent pending

Patient-specific technology: OptimalPSI's optimized patient-specific spinal fusion implant

Technology: Patient-specific optimization for improved load distribution

Improvement: Subsidence risk reduction and enhanced load distribution in pre-clinical testing*,**,***

Dr. Thijs Smit

Co-Founder & CEO

Founder credibility

Innovation Born from Rigorous Research

Dr. Thijs Smit developed OptimalPSI's optimization approach during his PhD at ETH Zürich under Prof. Stephen Ferguson. Now an official ETH Spin-off, OptimalPSI continues its collaboration with leading spine surgeon Dr. Daniel Haschtmann at Schulthess Klinik, where the technology was validated through computational modeling and biomechanical testing. This scientific foundation promises that our patient-specific spinal fusion implants deliver clinically meaningful improvements where traditional solutions fall short.

Meet Our Team